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Alcohol and Drug Abuse—Reward

Anderson CM, Rabi K, Lukas SE, Teicher MH. Cerebellar lingual size and experiential risk factors associated with high levels of alcohol and drug use in young adults. Cerebellum 2010; 9:198-209.

Bracken BK, Trksak GH, Penetar DM, Tartarini WL, Maywalt MA, Dorsey CM, Lukas SE. Response inhibition and psychomotor speed during methadone maintenance: impact of treatment duration, dose, and sleep deprivation. Drug Alcohol Depend. 2012 Sep 1;125(1-2):132-9.

Cowan R, Wood JK, Dietrich M, Frederick B, Lukas SE, Renshaw PF. Differential effects of d-amphetamine on red and blue light-induced photic activation: a novel BOLD fMRI assay of human dopamine function. Synapse 2008; 62(4): 268-272.

Gruber SA, Sagar KA, Dahlgren MK, Racine M, Lukas SE. Age of onset of marijuana use and executive function. Psychol Addict Behav 2012;26(3): 496-506. [Epub 2011 Nov 21]

Gruber SA, Sagar KA, Dahlgren MK, Olson, DP, Centorrino F, Lukas SE. Marijuana impacts mood in bipolar disorder: a pilot study. Ment Health Subst Abuse. 5(3):228-39, 2012.

Gruber SA, Dahlgren MK, Sagar KA, Gönenc A, Killgore WD. Age of onset of marijuana use impacts inhibitory processing. Neurosci Lett. 511(2):89-94, 2012.

Janes AC, Jensen JE, Farmer SL, Frederick BB, Pizzagalli DA, Lukas SE. (In Press) GABA levels in dorsal anterior cingulate cortex associated with difficulty ignoring smoking-related cues in tobacco-dependent volunteers. Neuropsychopharmacology

Janes AC, Nickerson L (co-first authors), Frederick BB, Kaufman MJ. (2012) Prefrontal and limbic resting state brain network functional connectivity differs between nicotine-dependent smokers and non-smoking controls. Drug and Alcohol Dependence, 125: 252-259.

Janes AC, Smoller JW, David SP, Frederick BB. Haddad S, Basu A, Fava M, Evins AE, Kaufman MJ. (2012) Association between CHRNA5 genetic variation at rs16969968 and brain reactivity to smoking images in nicotine dependent women. Drug and Alcohol Dependence, 120: 7-13.

Janes AC, Pizzagalli DA, Richardt S, Frederick BB, Holmes AJ, Sousa JA, Fava M, Evins AE, Kaufman MJ. (2010) Neural substrates of attentional bias for smoking-related cues: An fMRI study. Neuropsychopharmacology, 35: 2339-45.

Janes AC, Pizzagalli DA, Richardt S, Frederick BB, Chuzi S, Pachas G, Culhane MA, Holmes AJ, Fava M, Evins AE, Kaufman MJ. (2010) Brain reactivity to smoking cues prior to smoking cessation predicts ability to maintain tobacco abstinence. Biological Psychiatry, 67: 722-729.

Lee SH, Han DH, Oh S, Lyoo IK, Lee YS, Renshaw PF, Lukas SE. Quantitative electroencephalographic (qEEG) correlates of craving during virtual reality therapy in alcohol-dependent patients. Pharmacol Biochem Behav 2009; 91:393-397. Epub 2008 Aug 17.

Licata SC, Jensen JE, Penetar DM, Prescot AP, Lukas SE, Renshaw PF. A therapeutic dose of zolpidem reduces thalamic GABA in healthy volunteers: A proton MRS study at 4 Tesla. Psychopharmacology 2009; 203:819-29. [Epub Jan 6, 2009].

Licata SC, Mashhoon Y, MacLean RR, Lukas SE. (2011) Modest abuse-related subjective effects of zolpidem in drug-naïve volunteers. Behavioural Pharmacology 22: 160-166.

Licata SC, Nickerson LD, Lowen SB, Trksak GH, Maclean RR, Lukas SE. The hypnotic zolpidem increases the synchrony of BOLD signal fluctuations in widespread brain networks during a resting paradigm. Neuroimage 2013;70:211-222. Epub 2013 Jan 5

Lindsey KP, Bracken BK, Maclean RR, Ryan ET, Lukas SE, Frederick BD. Nicotine content and abstinence state have different effects on subjective ratings of positive versus negative reinforcement from smoking. Pharmacol Biochem Behav. 2013 Feb;103(4):710-6. Epub 2012 Dec 3.

Lindsey KP, Gatley SJ. Applications of clinical dopamine imaging. Neuroimaging Clin N Am. 2006 Nov;16(4):553-73, vii-viii. Review.

Liu X, Jensen JE, Gillis TE, Zuo CS, Prescot AP, Brimson M, Cayetano K, Renshaw PF, Kaufman MJ. Chronic cocaine exposure induces putamen glutamate and glutamine metabolite abnormalities in squirrel monkeys. Psychopharmacology 2011;217(3):367-75.

Lowen SB, Nickerson LD, Levin JM, “Differential effects of acute cocaine and placebo administration on visual cortical activation in healthy subjects measured using BOLD fMRI,” Pharmacology, Biochemistry, and Behavior 92, 277–282 (2009).

Lukas SE, Penetar D, Su Z, Geaghan T, Maywalt M, Tracy M, Rodolico J, Palmer C, Lee DYW. A standardized kudzu extract (NPI-031) reduces alcohol consumption in non treatment-seeking male heavy drinkers. Psychopharmacology 2013;226:65-73. Epub 2012 Oct 16.

Lukas SE, Lowen SB, Lindsey KP, Conn N, Tartarini W, Rodolico J, Mallya G, Palmer C, Penetar DM. Extended-Release Naltrexone (XR-NTX) Attenuates Brain Responses to Alcohol Cues in Alcohol-Dependent Volunteers: A BOLD fMRI Study. Neuroimage 2013;78:176-185.

Mashhoon Y, Jensen JE, Sneider JT, Yurgelun-Todd DA, Silveri MM (2013) Lower left-thalamic myo-Inositol levels associated with greater cognitive impulsivity in marijuana-dependent young men: preliminary spectroscopic evidence at 4T. Journal of Addiction Research and Therapy (in press)

Mashhoon Y, Janes AC, Jensen JE, Prescot AP, Pachas G, Renshaw PF, Fava M, Evins AE, Kaufman MJ. (2011) Anterior cingulate proton spectroscopy glutamate levels differ as a function of smoking cessation outcome. Progress in Neuro-psychopharmacology and Biological Psychiatry 35: 1709-1713

Mashhoon Y, Wells AM, Kantak KM. (2010) Interaction of the rostral basolateral amygdala and prelimbic prefrontal cortex in regulating reinstatement of cocaine-seeking behavior. Pharmacology, Biochemistry, and Behavior 96: 347-353.

Meade CS, Lowen S, MacLean RR, Key MD, Lukas SE, “fMRI brain activation during a delay discounting task in HIV-positive adults with and without cocaine dependence,” Psychiatry Research: Neuroimaging 192, 167–175 (2009).

Nickerson LD, Ravichandran C, Lundahl LH, Rodolico J, Dunlap S, Trksak G, Lukas SE. Cue-reactivity in cannabis-dependent adolescents. Psychology Addict Behav 2011;25: 168-173. Epub 2010 Dec 13.

Penetar DM, MacLean RR, McNeil JF, Lukas SE. Kudzu extract treatment does not increase the intoxicating effects of acute alcohol in human volunteers. Alcoholism: Clinical and Experimental Research, 2011, 35: 726-734.

Penetar DM, Lindsey KP, Peters EN, Juliano TM, Lukas SE. Decreasing nicotine content reduces subjective and physiological effects of smoking. Tobacco Use Insights, 2012, 5: 1-9.

Penetar DM, Toto LH, Farmer SL, Lee DY-W, Ma Z, Liu Y, Lukas SE. The isoflavone puerarin reduces alcohol intake in heavy drinkers: A pilot study. Drug and Alcohol Dependence, 2012, 126: 251-256.

Penetar DM, Burgos-Robles A, Trksak GH, MacLean RR, Dunlap S, Lee DY-W, Lukas SE. Effects of transcutaneous electric acupoint stimulation on drug use and responses to cue-induced craving: A pilot study. Chinese Medicine, 2012, 7:14.

Penetar DM, Looby AR, Ryan ET, Maywalt MA, Lukas SE. Bupropion reduces some of the symptoms of marihuana withdrawal in chronic marihuana users: A pilot study. Substance Abuse: Research and Treatment, 2012, 6: 63-71.

Silveri MM. Alcohol, adolescent brain development and the underage drinking policy in the United States: Identifying risks of alcohol use in college populations. Harvard Review of Psychiatry, 2012; 20(4):1-12.

Sneider JT, Gruber SA, Rogowska J, Silveri MM, Yurgelun-Todd DA. A preliminary study of functional brain activation among marijuana users during performance of a virtual water maze task. Journal of Addiction, 2013. [in press]

Sneider JT, Cohen-Gilbert JE, Crowley DJ, Paul MD, Silveri MM. Differential effects of binge drinking on learning and memory in emerging adults. Journal of Addiction Research and Therapy, Alcoholism Special Issue, 2013. [in press]

Wacker, J., Dillon, D.G., Pizzagalli, D.A. (2009). The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques. NeuroImage, 46, 327-337.

Yoon SJ, Lyoo IK, Kim HJ, Kim TS, Sung YH, Lukas SE, Renshaw PF. Neurochemical alterations in methamphetamine-dependent patients treated with cytidine-5'-diphosphate choline: a longitudinal proton magnetic resonance spectroscopy study. Neuropsychopharmacology. 2010 Apr;35(5):1165-73. Epub 2009 Dec 30.


Killgore, WD, Schwab, ZJ, Weber, M, Kipman, M, DelDonno, SR, Weiner, MR, & Rauch, SL. Daytime sleepiness affects prefrontal regulation of food intake. NeuroImage, 71, 216-223, 2013.

Killgore, WD, Weber, M, Schwab, ZJ, Kipman, M, DelDonno, SR, Webb, CA, & Rauch, SL. Cortico-limbic responsiveness to high-calorie food images predicts weight status among women. International Journal of Obesity (in press).

Killgore, WD. Self-reported sleep correlates with prefrontal-amygdala functional connectivity and emotional functioning. Sleep (in press).


Cohen-Gilbert, J.E. & Thomas, K.M. Inhibitory control during emotional distraction across adolescence and early adulthood. Child Development, 2013. [Epub ahead of print]

Fillipini N, Nickerson LD, Beckmann CF, Ebmeier KP, Frisoni GB, Matthews PM, Smith SM, Mackay CE. Effect of age on the functional architecture of the brain. NeuroImage 2012; 59(4):3821-3828. PMID: 22155375.

Forester BP, Berlow YA, Jensen JE, Cooper TM, Iosifescu DV, Lukas SE, Renshaw PF, Cohen BM. Age-related changes in brain energetics and phospholipid metabolism. NMR in Biomedicine. 2010; 23(3): 242-50. PMID: 19908224

Silveri MM, Sneider JT, Crowley DJ, Covell MJ, Acharya D, Rosso IM, Jensen JE. Frontal lobe GABA levels during adolescence: Associations with impulsivity and response inhibition. Biological Psychiatry, 2013. [Epub ahead of print]

Yoon SJ, Lyoo IK, Kim HJ, Kim TS, Sung YH, Kim N, Lukas SE, Renshaw PF. Forester BP, Berlow YA, Harper DG, Jensen JE, Lange N, Froimowitz MP, Ravichandran C, Iosifescu DV, Lukas SE, Renshaw PF, Cohen BM. Age-related changes in brain energetics and phospholipid metabolism. NMR Biomed 2010;23:242-250. Epub 2009 Nov 11.


Bogdan, R., Santesso, D.L., Fagerness, J., Perlis, R.H., Pizzagalli, D.A. (2011). Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning. Journal of Neuroscience, 31, 13246-13254.

Carey AN, Liu X, Mintzopoulos D, Paris JJ, Muschamp JW, McLaughlin JP, Kaufman MJ. Conditional Tat protein expression in the GT-tg bigenic mouse brain induces gray matter density reductions. Prog Neuropsychopharmacol Biol Psychiatry 2013;43(1):49-54. PMC3612135.

Pechtel, P., Pizzagalli, D.A. (2013). Disrupted reinforcement learning and maladaptive behavior in women with a history of childhood sexual abuse: A high-density event-related potential study. JAMA Psychiatry, 70, 499-507.

Wells AM, Janes AC, Liu X, Deschepper CF, Kaufman MJ, Kantak KM. Medial Temporal Lobe Functioning and Structure in the Spontaneously Hypertensive Rat: Comparison with Wistar–Kyoto Normotensive and Wistar–Kyoto Hypertensive Strains. Hippocampus 2010; 20(6):787-97. PMC2878848.

Methodology & Physics

Du F, Cooper A, Lukas SE, Cohen BM, Öngür D. Creatine kinase and ATP synthase reaction rates in human frontal lobe measured by 31P magnetization transfer spectroscopy at 4T. Magn Reson Imaging 2013;31:102-108. Epub Aug 13 2012.

Du F, Zhang Y, Zhu XH, Chen W. Simultaneously measuring glucose blood-brain transport constants and cerebral metabolic rate by in vivo 1H MRS in the rat brain. J Cereb Blood Flow Metab, 2012, 32, 1778-87.

Frederick BD, Nickerson LD, Tong Y. (2012) Physiological denoising of BOLD fMRI data using Regressor Interpolation at Progressive Time Delays (RIPTiDe) processing of concurrent fMRI and near-infrared spectroscopy (NIRS). Neuroimage, Apr 15;60(3): 1419-27.

Kaufman MJ, Janes AC, Frederick BdeB, Brimson-Theberge M, Tong Y, McWilliams SB, Bear A, Gillis TE, Schrode KM, Renshaw PF, Negus SS. A method for conducting functional MRI studies in alert nonhuman primates: initial results with opioid agonists in male cynomolgus monkeys. Experimental and Clinical Psychopharmacology (in press).

Lee CN, Wang YM, Lai WF, Chen TJ, Yu MC, Fang CL, Yu FL, Tsai YH, Chang WHS, Zuo CS, Renshaw PF. Superparamagnetic iron oxide nanoparticles for use in extrapulmonary tuberculosis diagnosis. Clinical Microbiology and Infection 2012

Lindsey KP, Lukas SE, MacLean RR, Ryan ET, Reed KR, Frederick Bd. Design and validation of an improved nonferrous smoking device for self-administration of smoked drugs with concurrent fMRI neuroimaging. Clin EEG Neurosci. 2009 Jan;40(1):21-30. PMID: 19278129

Lowen SB, Lukas SE, “A low-cost, MR-compatible olfactometer,” Behavior Research Methods 38, 307–313 (2006).

Nickerson LD, Martin CC, Lancaster JL, Gao JH, Fox PT. A tool for comparison of PET and fMRI methods: calculation of the uncertainty in the location of an activation site in a PET image. NeuroImage 2001; 14:194-201.

Nickerson LD, Narayana S, Lancaster JL, Fox PT, Gao JH. Estimation of the local statistical noise in positron emission tomography revisited: practical implementation. NeuroImage 2003; 19(2):442-456.

Tecilazich F, Dinh T, Lyons TE, Guest J, Villafuerte R, Sampanis C, Gnardellis C, Zuo C, Veves A, “Mitochondrial Dysfunction in Diabetic Patients With Neuropathy and Peripheral Arterial Disease”, Journal of Vascular Surgery, In Press.

Tong Y, Hocke L, Frederick BD. (2011) Isolating the sources of widespread physiological fluctuations in fNIRS signals. J Biomed Opt, Oct; 16(10):106005. PMID 22029352

Tong Y, Frederick BD. (2012) Concurrent fNIRS and fMRI processing allows independent visualization of the propagation of pressure waves and bulk blood flow in the cerebral vasculature. Neuroimage, Jul 16;61(4): 1419-27.

Tong Y, Hocke LM, Licata SC, Frederick BD. (2012) Low frequency oscillations measured in the periphery with near infrared spectroscopy (NIRS) are strongly correlated with blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) signals. J Biomed Opt, Oct; 17(10)

Tong Y, Hocke LM, Nickerson LD, Licata SC, Lindsey KP, Frederick BD. (2013) Evaluating the effects of systemic low frequency oscillations measured in the periphery on the independent component analysis results of resting state networks. Neuroimage, in press

Zuo CS, Sung YH, Simonson DC, et al, “Reduced T2* values in Soleus Muscle of patients with Type 2 Diabetes Mellitus”, PLoS One. 2012;7(11):e49337. doi: 10.1371/journal.pone.0049337.


Du F, Cooper A, Cohen BA, Renshaw PF, Öngür D. Water and Metabolite T2 Changes in the White Matter in Schizophrenia. Schizophr Res, 2012, 137, 241-5

Du F, Cooper A J, Thida T, Shinn A K, Cohen B M, Öngür D. Myelination and Axonal Abnormalities in Schizophrenia Measured using MRI Techniques. Biol Psychiatry, 2013 (in press)

Du F, Cooper A, Thida T, Sehovic S, Lukas S, Cohen B M, Zhang X L, Ongur D. In vivo Evidence for Abnormal Cerebral Bioenergetics in Schizophrenia Measured by 31P Magnetization Transfer Spectroscopy. JAMA Psychiatry, 2013 (in press)

Elman I, Lowen SB, Frederick Chi W, Becerra L, Pitman RK, “Functional neuroimaging of reward circuitry responsivity to monetary gains and losses in Posttraumatic Stress Disorder,” Biological Psychiatry 66, 1083–1090 (2009).

Forester B, Streeter CC, Berlow YA, Tian H, Wardrop M, Finn CT, Harper D, F. RP, Moore CM: Brain Lithium Levels and Effects on Cognition and Mood in Geriatric Bipolar Disorder. American Journal of Geriatric Psychiatry. 2009;17(1):13-23. PMID: 18626002

Forester BP, Harper DG, Jensen JE, Ravichandran C, Jordan B, Renshaw PF, Cohen BM. 31Phosphorus Magnetic Resonance Spectroscopy Study of Tissue Specific Changes in High Energy Phosphates Before and After Sertraline Treatment of Geriatric Depression. International Journal of Geriatric Psychiatry. 2009; 24(8):788-97. PMID: 19382284

Forester BP, Zuo CS, Ravichandran C, et al. Coenzyme Q10 Effects on Creatine Kinase Activity and Mood in Geriatric Bipolar Depression. Journal of Geriatric Psychiatry and Neurology 2012;25(1):43-50.

Gönenç A*, Wozniak J*, Biederman J, Moore CM, Joshi G, Georgiopoulos A, Hammerness P, McKillop H, Lukas SE, Henin A (* joint first authors). A magnetic resonance spectroscopy study of the anterior cingulated cortex in youth with emotional dysregulation. Isr J Psychiatry Relat Sci. 2012; 49(1):62-69.

Gönenç A, Frazier JA, Crowley DJ, Moore CM . Combined Diffusion Tensor Imaging and Transverse Relaxometry in Early-Onset Bipolar Disorder. Journal of the American Academy of Child & Adolescent Psychiatry. 2010; 49(12):1260-1268.

Henry ME, Lauriat TL, Lowen SB, Churchill JH, Hodgkinson CA, Goldman D, Renshaw PF, “Effects of citalopram and escitalopram on fMRI response to affective stimuli in healthy volunteers selected by serotonin transporter genotype,” Psychiatry Research: Neuroimaging (2013). (In press.)

Holmes, A.J., Pizzagalli, D.A. (2008). Spatio-temporal dynamics of error processing dysfunctions in Major Depressive Disorder. Archives of General Psychiatry, 65, 179-188.

Hooley JM, Siegle G, Gruber SA. Affective and neural reactivity to criticism in individuals high and low on perceived criticism. PLoS ONE, 7 (9): e44412. doi:10.1371/journal.pone.0044412, 2012.

Joshi G, Biederman J, Wozniak J, Goldin RL, Crowley D, Furtak S, Lukas SE, Gönenç A. Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: a pilot study at 4T. Eur Arch Psychiatry Clin Neurosci. 2012 Sep 18.

Killgore, WD, Schwab, ZJ, Tkachenko, O, Webb, CA, DelDonno, SR, Kipman M, Rauch SL, and Weber M. Emotional intelligence correlates with functional responses to dynamic changes in facial trustworthiness. Social Neuroscience (in press).

Ogata N, Gillis TE, Liu X, Cunningham SM, Lowen SB, Adams BL, Sutherland-Smith J, Mintzopoulos D, Janes AC, Dodman NH, Kaufman MJ. Brain structural abnormalities in Doberman Pinschers with canine compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry (in press).

Pizzagalli, D.A., Holmes, A.J., Dillon, D.G., Goetz, E.L., Birk, J.L., Bogdan, R., Dougherty, D.D., Iosifescu, D.V., Rauch, S.L., Fava, M. (2009). Reduced caudate and nucleus accumbens response to rewards in unmedicated subjects with Major Depressive Disorder. American Journal of Psychiatry, 166, 702-710.

Sagar KA, Dahlgren MK, Gönenc A, Gruber SA. Altered affective processing in bipolar disorder: an fMRI study. Journal of Affective Disorders. In press, 2013.

Wozniak J, Gönenç A, Biederman J, Moore C, Joshi G, Georgiopoulos A, Georgiopoulos A, Hammerness P, McKillop H, Lukas SE, Henin A. A Magnetic Resonance Spectroscopy Study of the Anterior Cingulate Cortex In Youth with Emotional Dysregulation. Isr J Psychiatry Relat Sci. 2012;49:62-69.


Killgore, WD, Schwab, ZJ, Kipman, M, DelDonno, SR, & Weber, M. Insomnia-related complaints correlate with functional connectivity between sensory-motor regions. Neuroreport, 24, 233-240, 2013.

Trksak GH, Jensen JE, Plante DT, Penetar DM, Tartarini WL, Maywalt MA, Brendel M, Dorsey CM, Renshaw PF, Lukas SE. Effects of sleep deprivation on sleep homeostasis and restoration during methadone-maintenance: a [31]P MRS brain imaging study. Drug Alcohol Depend. 2010 Jan 15;106(2-3):79-91.

Trksak GH, Jensen JE, Renshaw PF, Lukas SE. Brain phosphorus magnetic resonance spectroscopy imaging of sleep homeostasis and restoration in drug dependence. ScientificWorldJournal. 2007 Nov 2;7:217-22.

Winkelman JW, Plante DT, Schoerning L, Benson K, Buxton O, O’Connor SP, Jensen JE, Renshaw PF, Gönenç A . Increased rostral anterior cingulate cortex volume in chronic primary insomnia; SLEEP. 2013; (in press).