The Center Mr Scanners Contact Us Diagnostic Imaging Services Patient Information Referring Physicians Site Diagnostic Services Research McLean Imaging Center Applied Neuroimaging Statistics Laboratory CCNC fNIBI MIND Neurodevelopmental Lab on Addictions and Mental Health (NLAMH) Opto-Magnetic Group (OMG) Translational Imaging Translational Imaging Collaborations—Mclean Publications Publications Education N.I.D.A. T32 N.I.H. K Awards Northeastern CoOp MRI Techonlogist Training  

A.     Publications by Disorders 

Bipolar Disorder

Arat HE, Chouinard VA, Cohen BM, Lewandowski KE, Öngür D. Diffusion tensor imaging in first degree relatives of schizophrenia and bipolar disorder patients. Schizophr Res. 2015;161(2-3):329-39.

Baker JT, Holmes AJ, Masters GA, Yeo BTT, Krienen F, Buckner RL, Öngür D (2014) Disruption of cortical association networks in schizophrenia and psychotic bipolar disorder. JAMA Psychiatry, 71 (2): 109-18.

Berghorst LH, Kumar P, Greve DN, Deckersbach T, Ongur D, Dutra SJ, Pizzagalli DA. Stress and reward processing in bipolar disorder: a functional magnetic resonance imaging study. Bipolar Disord. 2016 Nov;18(7):602-11.

Du F, Yuksel C, Chouinard VA, Huynh P, Ryan K, Cohen BM, Öngür D. Abnormalities in high-energy phosphate metabolism in first-episode bipolar disorder measured using 31P-magnetic resonance spectroscopy. Biol Psychiatry. 2018;84(11):797-802.

Gruber SA, Dahlgren MK, Sagar KA, Gonenc A, Norris L, Cohen BM, Ongur D, Lewandowski KE. Decreased cingulate cortex activation during cognitive control processing in bipolar disorder. J Affect Disord. 2017;213:86-95.

Gruber SA, Rogowska J, Yurgelun-Todd, DA.  Decreased activation of the anterior cingulate in bipolar patients: An fMRI study. J Affect Disord. 2004; 82(2):191-201.

Loeber RT, Gruber SA, Cohen BM, Renshaw PF, Sherwood AR, Yurgelun-Todd DA.  Cerebellar blood volume in bipolar patients correlates with medication. Biol Psychiatry. 2002;51(5):370-6.

Reich DB, Belleau EL, Temes CM, Gonenc A, Pizzagalli DA, Gruber SA. Amygdala resting state connectivity differences between Bipolar II and Borderline Personality Disorders. Neuropsychobiology. 2019;78(4):229-37.

Sagar KA, Dahlgren MK, Gönenc A, Gruber SA. Altered affective processing in bipolar disorder: an fMRI study. J Affect Disord. 2013;150(3):1192-6.


Admon R*, Kaiser RH*, Dillon DG, Beltzer M, Goer F, Olson DP, Vitaliano G, Pizzagalli DA. Dopaminergic enhancement of striatal response to reward in major depression. Am J Psychiatry 2017;174(4):378-86.  [*Co-first authors]

Henry ME, Kaufman MJ, Hennen J, Michelson D, Schmidt ME, Stoddard E, Vukovic AJ, Barreira PJ, Cohen BM, Renshaw PF. Cerebral blood volume and clinical changes on the third day of placebo substitution for SSRI treatment. Biol. Psychiatry 2003;53:100-5.

Ironside M*, Amemori K-I*, McGrath CL, Pedersen ML, Kang MS, Amemori S, Frank MJ, Graybiel AM, Pizzagalli DA. Approach-avoidance conflict in major depression: Congruent neural findings in human and non-human primates. Biol Psychiatry 2020;87(5), 399-408. * Equal contribution

Janes AC, Zegel M, Ohashi K, Betts J, Molokotos E, Olson D, Moran L, Pizzagalli DA. Nicotine normalizes cortico-striatal connectivity in non-smoking individuals with major depressive disorder. Neuropsychopharmacology. 2018;43(12):2445-51.

Kaufman MJ, Henry MH, Frederick BdeB, Hennen J, Villafuerte RA, Stoddard E, Schmidt ME, Cohen BM, Renshaw PF.  Selective Serotonin Reuptake Inhibitor discontinuation syndrome is associated with a rostral anterior cingulate choline metabolite decrease:  A Proton Magnetic Resonance Spectroscopic imaging study. Biol. Psychiatry 2003;54:534-9.

McLaughlin JP, Paris JJ, Mintzopoulos D, Hymel KA, Kim JK, Cirino TJ, Gillis TE, Eans SO, Vitaliano GD, Medina JM, Krapf RC, Stacy JM, Kaufman MJ. Conditional HIV-Tat protein expression induces depression-like effects and oxidative stress. Biol Psychiatry: Cognitive Neurosci Neuroimaging 2017;2:599-609.

Pizzagalli DA, Berretta S, Wooten D, Goer F, Pilobello KT, Kumar P, Murray L, Beltzer M, Boyer-Boiteau A, Alpert N, El Fakhri G, Mechawar N, Vitaliano G, Turecki G, Normandin M. Assessment of striatal dopamine transporter binding in individuals with major depressive disorder: In vivo positron emission tomography and postmorten evidence. JAMA Psychiatry 2019;76(8):854-861.

Drug and Alcohol Use Disorders

Anderson CM, Maas LC, Frederick BdeB, Bendor JT, Spencer TJ, Livni E, Lukas SE, Fischman AJ, Madras BK, Renshaw PF, Kaufman MJ. Cerebellar vermis involvement in cocaine-related behaviors. Neuropsychopharmacology 2006;31:1318-26.

Copersino ML, Patel R, Price JS, Visser KF, Vitaliano G, Plitman E, Lukas SE, Weiss RD, Janes AC, Chakravarty MM. Interactive effects of age and recent substance use on striatal shape morphology at substance use disorder treatment entry. Drug Alcohol Depend. 2019; 9:107728.

Gruber SA, Sagar KA, Dahlgren MK, Gonenc A, Smith RT, Lambros AM, Cabrera KB, Lukas SE. The grass might be greener: Medical marijuana patients exhibit altered brain activity and improved executive function after 3 months of treatment. Front Pharmacol. 2018;8:983. doi: 10.3389/fphar.2017.00983. eCollection 2017.

Gruber SA, Dahlgren MK, Sagar KA, Gönenc A, Killgore WD. Age of onset of marijuana use impacts inhibitory processing. Neurosci Lett. 2012;511(2):89-94. 

Gruber SA, Dahlgren MK, Sagar KA, Gönenç A, Lukas SE. Worth the wait: effects of age of onset of marijuana use on white matter and impulsivity. Psychopharmacology (Berl). 2014;231(8):1455-65.

Gruber SA, Sagar KA, Dahlgren MK, Gonenc A, Conn NA, Winer JP, Penetar D, Lukas SE.  Citicoline treatment improves measures of impulsivity and task performance in chronic marijuana smokers: a pilot BOLD fMRI study. Int J Neurol Neurother. 2015;2(3):1-8. 

Gruber SA, Silveri MM, Dahlgren MK, Yurgelun-Todd DA.  Why so Impulsive? White matter alterations are associated with impulsivity in chronic marijuana smokers.  Exp Clin Psychopharmacol.  2011;19(3):231-42. 

Hasbi A, Madras BK, Bergman J, Kohut S, Lin Z, Withey SL, George SR. (2020) THC (?9-Tetrahydrocannabinol) elicits dramatic increase in dopamine D1-D2 receptor heteromer with phenotypic reprogramming of adult primate striatal neurons: Attenuation by CBD (Cannabidiol). iScience, 23(1): 100794.

Hill KP, Palastro MD, Gruber SA, Fitzmaurice GM, Greenfield SF, Lukas SE, Weiss RD. Nabilone pharmacotherapy for cannabis dependence: A randomized, controlled pilot study. Am J Addict 2017; 26:795-801.

Janes AC, Pizzagalli DA, Richardt S, Frederick BdeB, Chuzi S, Pachas G, Culhane MA, Holmes AJ, Fava M, Evins AE, Kaufman MJ. Brain reactivity to smoking cues prior to smoking cessation predicts ability to maintain tobacco abstinence.  Biol. Psychiatry 2010;67(8):722-9.

Janes AC, Krantz NL, Nickerson LD, Frederick BB, Lukas SE. Craving and cue reactivity in nicotine-dependent tobacco smokers is associated with different insula networks. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020;5(1):76-83.

Kaufman MJ, Janes AC, Frederick BdeB, Brimson-Theberge M, Tong Y, McWilliams SB, Bear A, Gillis TE, Schrode KM, Renshaw PF, Negus SS.  A method for conducting functional MRI studies in alert nonhuman primates: initial results with opioid agonists in male cynomolgus monkeys.  Exp Clin. Psychopharmacol. 2013;21:323-31.

Kaufman MJ, Janes AC, Hudson JI, Brennan BP, Kanayama G, Kerrigan AR, Jensen JE, Pope HG Jr. Brain and cognition abnormalities in long-term anabolic-androgenic steroid users. Drug Alcohol Depend. 2015;152:47-56.

Kohut SJ, Kaufman ML. Magnetic resonance spectroscopy studies of substance use disorders: Current landscape and potential future directions. Pharmacol Biochem Behav. 2021 Jan;200:173090. doi: 10.1016/j.pbb.2020.173090.

Kohut SJ, Mintzopoulos D, Kangas BD, Shields H, Brown K, Gillis TE, Rohan ML, Bergman J, Kaufman MJ. Effects of long-term cocaine self-administration on brain resting state functional connectivity in nonhuman primates. Transl Psychiatry, 10, 420 (2020).

Li H, Smith SM, Gruber S, Lukas SE, Silveri MM, Hill KP, Killgore WDS, Nickerson LD. Denoising scanner effects from multimodal MRI data using linked independent component analysis. Neuroimage. 2019;208:116388. 

Lindsey KP, Bracken BK, Maclean RR, Ryan ET, Lukas SE, Frederick BD. Nicotine content and abstinence state have different effects on subjective ratings of positive versus negative reinforcement from smoking. Pharmacol Biochem Behav. 2013;103(4):710-6.

Lowen SB, Farmer SL, Lukas SE. Improved low-cost, MR-compatible olfactometer to deliver tobacco smoke odor. Behav Res Methods. 2017;49(1):74-82.

Lukas SE. New perspectives on using brain imaging to study CNS stimulants. Neuropharmacology. 2014;87:104-14

Lukas SE, Lowen SB, Lindsey KP, Conn N, Tartarini W, Rodolico J, Mallya G, Palmer C, Penetar DM. Extended-release naltrexone (XR-NTX) attenuates brain responses to alcohol cues in alcohol-dependent volunteers: a bold FMRI study. Neuroimage. 2013;78:176-85.

Maksimovskiy AL, Oot EN, Seraikas AM, Rieselbach M, Caine C, Sneider JT, Cohen-Gilbert JE, Harris SK, Nickerson LD, Rohan ML, Silveri MM. Morphometric biomarkers of adolescents with familial risk for alcohol use disorder. Alcohol Clin Exp Res. 2019;43(11):2354-66.

Mashhoon Y, Betts J, Farmer SL, Lukas SE.  Early onset cigarette smokers exhibit greater P300 reactivity to smoking-related stimuli and report greater craving. Brain Res 2018;1687:173-184.

Mashhoon Y, Czerkawski C, Crowley DJ, Cohen-Gilbert JE, Sneider JT, Silveri MM. Binge alcohol consumption in emerging adults: anterior cingulate cortical "thinness" is associated with alcohol use patterns. Alcohol Clin Exp Res. 2014;38(7):1955-64.

McCarthy J, Zuo C, Shepherd J, Dias N, Lukas SE, Janes A. Reduced interhemispheric executive control network coupling in men during early cocaine abstinence: A pilot study. Drug Alcohol Depend 2017; 181:1-4. 

Sagar KA, Dahlgren MK, Gonenc A, Racine MT, Dreman MW, Gruber SA. The impact of initiation: Marijuana smokers demonstrate altered Stroop performance and brain activation. Dev Cogn Neurosci. 2015;16:84-92.

Sagar KA, Gruber SA. Interactions between recreational cannabis use and cognitive function: lessons from functional magnetic resonance imaging. Ann N Y Acad Sci. 2019;1451(1):42-70.

Sneider JT, Cohen-Gilbert JE, Hamilton DA, Stein ER, Golan N, Oot EN, Seraikas AM, Rohan ML, Harris SK, Nickerson LD, Silveri MM. Adolescent hippocampal and prefrontal brain activation during performance of the virtual Morris Water Task. Front Hum Neurosci. 2018;12:238. doi: 10.3389/fnhum.2018.00238. eCollection 2018

Wang KS, Zegel M, Molokotos E, Moran LV, Olson DP, Pizzagalli DA, Janes AC. The acute effects of nicotine on corticostriatal responses to distinct phases of reward processing. Neuropsychopharmacology. 2020;45(7):1207-1214.

Geriatric Mood Disorders

Forester BP, Harper DG, Jensen JE, Ravichandran C, Jordan B, Renshaw PF, Cohen BM. 31Phosphorus magnetic resonance spectroscopy study of tissue specific changes in high energy phosphates before and after sertraline treatment of geriatric depression. Int J Geriatr Psychiatry. 2009;24(8):788-97

Harper DG, Joe EB, Jensen JE, Ravichandran C, Forester BP. Brain levels of high-energy phosphate metabolites and executive function in geriatric depression. Int J Geriatr Psychiatry. 2016;31(11):1241-9.

Mellen EJ, Harper DG, Ravichandran C, Jensen E, Silveri M, Forester BP. Lamotrigine therapy and biomarkers of cerebral energy metabolism in older age bipolar depression. Am J Geriatr Psychiatry. 2019;27(8):783-93.

Obsessive-Compulsive Disorder 

Brennan BP, Jensen JE, Perriello C, Pope HG Jr, Jenike MA, Hudson JI, Rauch SL, Kaufman MJ. Lower posterior cingulate cortex glutathione levels in obsessive-compulsive disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016;1(2):116-24

Brennan BP, Tkachenko O, Schwab ZJ, Juelich RJ, Ryan EM, Athey AJ, Pope HG, Jenike MA, Baker JT, Killgore WD, Hudson JI, Jensen JE, Rauch SL. An examination of rostral anterior cingulate cortex function and neurochemistry in Obsessive-Compulsive Disorder. Neuropsychopharmacology. 2015;40(8):1866-76.

Brennan BP, Wang D, Li M, Perriello C, Ren J, Elias JA, Van Kirk NP, Krompinger JW, Pope HG Jr, Haber SN, Rauch SL, Baker JT, Liu H. Use of an individual-level approach to identify cortical connectivity biomarkers in obsessive-compulsive disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019;4(1):27-38.

Post-traumatic Stress Disorder

Dahlgren MK, Laifer LM, VanElzakker M, Offringa R, Hughes KC, Staples-Bradley LK, Dubois SJ, Lasko NB, Orr SP, Pitman RK, Shin LM. Diminished medial prefrontal cortex activation during the recollection of stressful events is an acquired characteristic of PTSD. Psychol Med. 2018;48(7):1128-38. 

Harnett NG, Stevens JS, van Rooij SJH, Ely TD, Michopoulos V, Hudak L, Jovanovic T, Rothbaum BO, Ressler KJ, Fani N. Multimodal structural neuroimaging markers of risk and recovery from posttrauma anhedonia: A prospective investigation. Depress Anxiety. 2021;38(1):79-88.

Lebois LAM, Li M, Baker JT, Wolff JD, Wang D, Lambros AM, Grinspoon E, Winternitz S, Ren J, Gönenç A, Gruber SA, Ressler KJ, Liu H, Kaufman ML. Large-scale functional brain network architecture changes associated with trauma-related dissociation. Am J Psychiatry. 2021;178(2):165-173

Olson EA, Kaiser RH, Pizzagalli DA, Rauch SL, Rosso IM. Regional prefrontal resting-state functional connectivity in posttraumatic stress disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019;4(4):390-8.

Rosso IM, Crowley DJ, Silveri MM, Rauch SL, Jensen JE. Hippocampus glutamate and N-Acetyl Aspartate markers of excitotoxic neuronal compromise in Posttraumatic Stress Disorder. Neuropsychopharmacology. 2017;42(8):1698-705.


Baker JT, Dillon DG, Patrick LM, Roffman JL, Brady RO Jr, Pizzagalli DA, Öngür D, Holmes AJ. Functional connectomics of affective and psychotic pathology. Proc Natl Acad Sci U S A. 2019;116(18):9050-9059

Baker JT, Holmes AJ, Masters GA, Yeo BT, Krienen F, Buckner RL, Öngür D. Disruption of cortical association networks in schizophrenia and psychotic bipolar disorder. JAMA Psychiatry. 2014;71(2):109-18.

Du F, Cooper AJ, Thida T, Shinn AK, Cohen BM, Ongür D. Myelin and axon abnormalities in schizophrenia measured with magnetic resonance imaging techniques. Biol Psychiatry. 2013;74(6):451-7.

Du F, Yuksel C, Chouinard VA, Huynh P, Ryan K, Cohen BM, Öngür D. Abnormalities in high-energy phosphate metabolism in first-episode bipolar disorder measured using 31P-Magnetic Resonance Spectroscopy. Biol Psychiatry. 2018;84(11):797-802.

Kim SY, Cohen BM, Chen X, Lukas SE, Shinn AK, Yuksel AC, Li T, Du F, Öngür D. Redox dysregulation in schizophrenia revealed by in vivo NAD+/NADH measurement. Schizophr Bull. 2017;43(1):197-204. 

Kim SY, Kaufman MJ, Cohen BM, Jensen JE, Coyle JT, Du F, Öngür D. In vivo brain glycine and glutamate concentrations in patients with first-episode psychosis measured by echo time-averaged proton magnetic resonance spectroscopy at 4T. Biol Psychiatry. 2018;83(6):484-91.

Lewandowski KE, McCarthy JM, Öngür D, Norris LA, Liu GZ, Juelich RJ, Baker JT. Functional connectivity in distinct cognitive subtypes in psychosis.  Schizophrenia Res 2019;204:120-6.

Moran LV, Stoeckel LE, Wang K, Caine CE, Villafuerte R, Calderon V, Baker JT, Ongur D, Janes AC, Evins AE, Pizzagalli DA. Nicotine-induced activation of caudate and anterior cingulate cortex in response to errors in schizophrenia. Psychopharmacology (Berl). 2018;235(3):789-802. 

Shinn AK, Baker JT, Cohen BM, Öngür D. Functional connectivity of left Heschl's gyrus in vulnerability to auditory hallucinations in schizophrenia. Schizophrenia Res. 2013;143:260-8.

Song X, Chen X, Yuksel C, Yuan J, Pizzagalli DA, Forester B, Öngür D, Du F. Bioenergetics and abnormal functional connectivity in psychotic disorders. Mol Psychiatry. 2021 Jan 4. doi: 10.1038/s41380-020-00993-z. Online ahead of print.

Yuksel C, Chen X, Chouinard VA, Nickerson LD, Gardner M, Cohen T, Öngür D, Du F. Abnormal brain bioenergetics in first-episode psychosis. Schizophr Bull Open. 2021 Jan 30;2(1):sgaa073. doi: 10.1093/schizbullopen/sgaa073. eCollection 2021

B.     Publications by Applications

Biomarkers of Treatment Response

Ang Y-S, Kaiser R, Deckersbach T, Almeida J, Phillips ML, Chase HW, Webb CA, Parsey R, Fava M, McGrath P, Weissman M, Adams P, Deldin P, Oquendo MA, McInnis MG, Carmody T, Bruder G, Cooper CM, Chin Fatt CR, Trivedi MH, Pizzagalli DA. Pretreatment reward sensitivity and frontostriatal resting-state functional connectivity are associated with response to bupropion after sertraline non-response. Biol Psychiatry 2020;88(8):657-667.

Pizzagalli DA*, Webb CA*, Dillon DG, Tenke CE, Kayser J, Goer F, Fava M, McGrath P, Weissman M, Parsey R, Adams P, Trombello J, Cooper C, Deldin P, Oquendo MA, McInnis MG, Carmody T, Bruder G, Trivedi MH. Pretreatment rostral anterior cingulate cortex activity in relation to symptom improvements in depression: A randomized clinical trial. JAMA Psychiatry 2018;75(6):547-54. [*Equal contributions]. 

Webb CA, Auerbach RP, Bondy E, Stanton CH, Appleman L, Pizzagalli DA (in press). Reward-related neural predictors and mechanisms of symptom change in cognitive behavioral therapy for depressed adolescent girls. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021;6(1):39-49.

Whitton AE, Webb CA, Dillon DG, Kayser J, Rutherford A, Goer F, Fava M, McGrath P, Weissman M, Parsey R, Adams P, Trombello JM, Cooper C, Deldin P, Oquendo MA, McInnis MG, Carmody T, Bruder G, Trivedi MH, Pizzagalli DA. Pre-treatment rostral anterior cingulate cortex connectivity with salience network predicts depression recovery: Findings from the EMBARC randomized clinical trial. Biol Psychiatry 2019;85(10):872-880.

Whitton AE, Reinen JM, Slifstein M, Ang Y-S, McGrath PJ, Iosifescu DV, Abi-Dargham A, Pizzagalli DA*, Schneier FR* (2020). Baseline reward processing and ventrostriatal dopamine function are associated with pramipexole response in depression. Brain, 143, 701-710. [*Equal senior contribution]

Brain Stimulation Methods

Mintzopoulos D, Gillis, TE, Tedford CE, Kaufman MJ. Effects of near infrared light on cerebral bioenergetics measured with phosphorus magnetic resonance spectroscopy. Photomed Laser Surg. 2017;35:395-400.

Rohan M, Parow A, Stoll AL, Demopulos C, Friedman S, Dager S, Hennen J, Cohen BM, Renshaw PF. Low-field magnetic stimulation in bipolar depression using an MRI-based stimulator. Am J Psychiatry. 2004;161(1):93-8.

Rohan ML, Yamamoto RT, Ravichandran CT, Cayetano KR, Morales OG, Olson DP, Vitaliano G, Paul SM, Cohen BM. Rapid mood-elevating effects of low field magnetic stimulation in depression. Biol Psychiatry. 2014;76(3):186-93.

Detection of Cerebrovascular Pathology 

Donahue MJ, Strother MK, Lindsey KP, Hocke LM, Tong Y, Frederick BD. Time delay processing of hypercapnic fMRI allows quantitative parameterization of cerebrovascular reactivity and blood flow delays. J Cereb Blood Flow Metab. 2016;36(10):1767-79.


Ang Y-S, Frontero N, Belleau E, Pizzagalli DA (2020). Disentangling vulnerability, state and trait features of neurocognitive impairments in depression. Brain. 2020;143(12):3865-77. 

Auerbach RP, Pisoni A, Bondy E, Kumar P, Stewart JG, Yendiki A, Pizzagalli DA. Neuroanatomical prediction of anhedonia in adolescents. Neuropsychopharmacology. 2017;42(10):2087-95.

Belleau EL, Kremens R, Ang Y-S, Pisoni A, Bondy E, Durham K, Auerbach RP*, Pizzagalli DA* (2020). Reward functioning abnormalities in adolescents at high familial risk for depressive disorders. Biol Psychiatry: Cogn Neurosci Neuroimaging. 2020 Sep 6:S2451-9022(20)30251-2. doi: 10.1016/j.bpsc.2020.08.016. Online ahead of print. [Equal senior contribution]

Cohen-Gilbert JE, Jensen JE, Silveri MM. Contributions of magnetic resonance spectroscopy to understanding development: potential applications in the study of adolescent alcohol use and abuse. Dev Psychopathol. 2014;26(2):405-23. 

Fillipini N, Nickerson LD, Beckmann CF, Ebmeier KP, Frisoni GB, Matthews PM, Smith SM, Mackay CE. Effect of age on the functional architecture of the brain. NeuroImage 2012; 59(4):3821-8. 

Forester BP, Berlow YA, Jensen JE, Cooper TM, Iosifescu DV, Lukas SE, Renshaw PF, Cohen BM. Age-related changes in brain energetics and phospholipid metabolism. NMR Biomed. 2010; 23(3): 242-50. 

Kaiser RH, Peterson E, Kang M-S, Van Der Feen J, Aguirre B, Clegg R, Goer F, Esposito EC, Auerbach RP, Pizzagalli DA. Frontoinsular network markers of current and future adolescent mood health. Biol Psychiatry Cogn Neurosci Neuroimaging . 2019;4(8):715-25. 

Silveri MM, Sneider JT, Crowley DJ, Covell MJ, Acharya D, Rosso IM, Jensen JE. Frontal lobe GABA levels during adolescence: Associations with impulsivity and response inhibition. Biol Psychiatry. 2013;74(4):296-304.

Yoon SJ, Lyoo IK, Kim HJ, Kim TS, Sung YH, Kim N, Lukas SE, Renshaw PF. Forester BP, Berlow YA, Harper DG, Jensen JE, Lange N, Froimowitz MP, Ravichandran C, Iosifescu DV, Lukas SE, Renshaw PF, Cohen BM. Age-related changes in brain energetics and phospholipid metabolism. NMR Biomed 2010;23:242-250. 


Bogdan, R., Santesso, D.L., Fagerness, J., Perlis, R.H., Pizzagalli, D.A. (2011). Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning. J Neurosci. 2011;31:13246-54.

Carey AN, Liu X, Mintzopoulos D, Paris JJ, Muschamp JW, McLaughlin JP, Kaufman MJ. Conditional Tat protein expression in the GT-tg bigenic mouse brain induces gray matter density reductions. Prog Neuropsychopharmacol Biol Psychiatry 2013;43(1):49-54.

Guffanti G, Kumar P, Admon R, Treadway, M.T., Hall, M., Mehta, M., Douglas, S., Arulpragasam, A.R., Pizzagalli, D.A. (2019). Depression genetic risk score is associated with anhedonia-related markers across units of analysis. Transl Psychiatry. 2019 Sep 19;9(1):236. doi: 10.1038/s41398-019-0566-7.

Lee PH, Baker JT, Holmes AJ, Jahanshad N, Ge T, Jung J-Y, Cruz Y, Manoach DS, Hibar DP, Faskowitz J, McMahon KL, de Zubicaray GI, Martin, NH, Wright MJ, Öngür D, Buckner RL, Roffman J, Thompson PM, Smoller JW (2016) Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia.  Mol Psychiatry. 2016;21(12):1680-9.

Wells AM, Janes AC, Liu X, Deschepper CF, Kaufman MJ, Kantak KM. Medial temporal lobe functioning and structure in the spontaneously hypertensive rat: Comparison with Wistar–Kyoto normotensive and Wistar–Kyoto hypertensive strains. Hippocampus 2010; 20(6):787-97.

Proof-of-Mechanism Studies

Krystal AD, Pizzagalli DA, Smoski M, Mathew SJ, Nurnberger J Jr, Lisanby SH, Iosifescu D, Murrough JW, Yang H, Weiner RD, Calabrese JR, Sanacora G, Hermes G, Keefe RSE, Song A, Goodman W, Szabo ST, Whitton AE, Gao K, Potter WZ. A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating ?-opioid antagonism as a treatment for anhedonia. Nat Med. 2020;26(5):760-768. 

Peripheral Vascular Physiology Characterization

Li Y, Ma Y, Ma S, Liang Z, Xu F, Tong Y, Frederick BD, Yin S, Li X. Asymmetry of peripheral vascular biomarkers in ischemic stroke patients, assessed using NIRS. J Biomed Opt. 2020;25(6):1-16. 

Li Y, Zhang H, Yu M, Yu W, Frederick BD, Tong Y. Systemic low-frequency oscillations observed in the periphery of healthy human subjects. J Biomed Opt. 2018;23(5):1-11. 


Benson KL, Bottary R, Schoerning L, Baer L, Gonenc A, Eric Jensen J, Winkelman JW.  1H MRS measurement of cortical GABA and glutamate in primary insomnia and major depressive disorder: Relationship to sleep quality and depression severity. J Affect Disord. 2020;274:624-31. 

Licata SC, Nickerson LD, Lowen SB, Trksak GH, Maclean RR, Lukas SE. The hypnotic zolpidem increases the synchrony of BOLD signal fluctuations in widespread brain networks during a resting paradigm. Neuroimage. 2013;70:211-22. 

Plante DT, Trksak GH, Jensen JE, Penetar DM, Ravichandran C, Riedner BA, Tartarini WL, Dorsey CM, Renshaw PF, Lukas SE, Harper DG. Gray matter-specific changes in brain bioenergetics after acute sleep deprivation: a 31P magnetic resonance spectroscopy study at 4 Tesla. Sleep. 2014;37(12):1919-27.

Trksak GH, Jensen JE, Plante DT, Penetar DM, Tartarini WL, Maywalt MA, Brendel M, Dorsey CM, Renshaw PF, Lukas SE. Effects of sleep deprivation on sleep homeostasis and restoration during methadone-maintenance: a [31]P MRS brain imaging study. Drug Alcohol Depend. 2010;106(2-3):79-91.

Trksak GH, Jensen JE, Renshaw PF, Lukas SE. Brain phosphorus magnetic resonance spectroscopy imaging of sleep homeostasis and restoration in drug dependence. ScientificWorldJournal. 2007 Nov 2;7:217-22.

Winkelman JW, Plante DT, Schoerning L, Benson K, Buxton O, O’Connor SP, Jensen JE, Renshaw PF, Gönenç A. Increased rostral anterior cingulate cortex volume in chronic primary insomnia; Sleep. 2013;36(7):991-8. 

C.     Methodology & Physics

Dynamic Functional Connectivity/Co-Pattern Coactivation Analysis

Janes AJ, Peechatka AL, Frederick BB, Kaiser RH. Dynamic functioning of transient resting-state coactivation networks in the Human Connectome Project. Hum Brain Mapp. 2020;41(2):373-87.

Kaiser RH, Kang M, Lew Y, Van Der Feen J, Aguirre B, Clegg R, Goer F, Esposito E, Auerbach RP, Hutchison RM, Pizzagalli DA. Abnormal frontoinsular-default network dynamics in adolescent depression and rumination: A preliminary resting-state co-activation pattern analysis. Neuropsychopharmacology 2019; 44(9):1604-12. 

Wang KS, Kaiser RH, Peechatka AL, Frederick BB, Janes AC. Temporal dynamics of large-scale networks predict neural cue reactivity and cue-induced craving. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020;5(11):1011-1018.

Independent Component Analysis Development

Zhao W, Li H, Hu G, Hao Y, Zhang Q, Wu J, Frederick BB, Cong F. Consistency of Independent Component Analysis for FMRI. J Neurosci Methods. 2020 Dec 11;351:109013. doi: 10.1016/j.jneumeth.2020.109013. Online ahead of print. 

Linked Independent Component Analysis

Li H, Smith SM, Gruber S, Lukas SE, Silveri MM, Hill KP, Killgore WDS, Nickerson LD. Denoising scanner effects from multimodal MRI data using linked independent component analysis. Neuroimage. 2020 Mar;208:116388. doi: 10.1016/j.neuroimage.2019.116388. 

Nickerson LD, Smith SM, Öngür D, Beckmann CF. Using dual regression to investigate network shape and amplitude in functional connectivity analyses. Front Neurosci. 2017 Mar 13;11:115. doi: 10.3389/fnins.2017.00115. eCollection 2017.

Machine Learning

Aslan S, Hocke L, Schwarz N, Frederick B. Extraction of the cardiac waveform from simultaneous multislice fMRI data using slice sorted averaging and a deep learning reconstruction filter. Neuroimage. 2019;198:303-16. 

Liu Y, Admon R, Mellem MS, Belleau EM, Kaiser RH, Clegg R, Beltzer M, Goer F, Vitaliano G, Ahammad P, Pizzagalli DA. Machine learning identifies large-scale reward-related activity modulated by dopaminergic enhancement in major depression. Biol Psychiatry Cogn Neurosci Neuroimaging . 2020;5(2):163-72. 

Wang D, Li M, Wang M, Schoeppe F, Ren J, Chen H, Öngür D, Brady RO, Baker JT, Liu H. Individual-specific functional connectivity markers track dimensional and categorical features of psychotic illness.  Mol Psychiatry, 2018; 25:2119-29.

Magnetization Transfer Spectroscopy 

Du F, Cooper A, Lukas SE, Cohen BM, Öngür D. Creatine kinase and ATP synthase reaction rates in human frontal lobe measured by 31P magnetization transfer spectroscopy at 4T. Magn Reson Imaging 2013;31:102-8.

Du F, Yuksel C, Chouinard VA, Huynh P, Ryan K, Cohen BM, Öngür D. Abnormalities in high-energy phosphate metabolism in first-episode bipolar disorder measured using (31)P-Magnetic Resonance Spectroscopy. Biol Psychiatry. 2018;84(11):797-802.


Vitaliano GD, Vitaliano F, Rios JD, Renshaw PF, Teicher MH. New clathrin-based nanoplatforms for magnetic resonance imaging. PLoS One. 2012;7(5):e35821. doi: 10.1371/journal.pone.0035821.

Near Infrared Spectroscopy Development

Fantini S, Frederick B, Sassaroli A. Perspective: Prospects of non-invasive sensing of the human brain with diffuse optical imaging. APL Photonics.2018 Nov;3(11). doi: 10.1063/1.5038571. 

Hocke LM, Cayetano K, Tong Y, Frederick B. Optimized multimodal functional magnetic resonance imaging/near-infrared spectroscopy probe for ultrahigh-resolution mapping. Neurophotonics. 2015 Oct;2(4):045004. doi: 10.1117/1.NPh.2.4.045004. 

Hocke LM, Oni IK, Duszynski CC, Corrigan AV, Frederick BD, Dunn JF. Automated processing of fNIRS data-A visual guide to the pitfalls and consequences. Algorithms. 2018 May;11(5). doi: 10.3390/a11050067. 

Physiological Noise Characterization and Removal

Erdo?an SB, Tong Y, Hocke LM, Lindsey KP, Frederick B. Correcting for blood arrival time in global mean regression enhances functional connectivity analysis of resting state fMRI-BOLD signals.  Front Hum Neurosci. 2016;10:311. doi: 10.3389/fnhum.2016.00311. eCollection 2016. 

Frederick BD, Nickerson LD, Tong Y. Physiological denoising of BOLD fMRI data using Regressor Interpolation at Progressive Time Delays (RIPTiDe) processing of concurrent fMRI and near-infrared spectroscopy (NIRS). Neuroimage. 2012;60(3):1913-23.

Hocke LM, Tong Y, Lindsey KP, de B Frederick B. Comparison of peripheral near-infrared spectroscopy low-frequency oscillations to other denoising methods in resting state functional MRI with ultrahigh temporal resolution. Magn Reson Med. 2016 Dec;76(6):1697-1707. 

Hocke LM, Frederick BB. Post-hoc physiological waveform extraction from motion estimation in simultaneous multislice (SMS) functional MRI using separate stack processing. Magn Reson Med. 2021 Jan;85(1):309-315. 

Sutoko S, Chan YL, Obata A, Sato H, Maki A, Numata T, Funane T, Atsumori H, Kiguchi M, Tang TB, Li Y, Frederick BD, Tong Y. Denoising of neuronal signal from mixed systemic low-frequency oscillation using peripheral measurement as noise regressor in near-infrared imaging.  Neurophotonics. 2019 Jan;6(1):015001. doi: 10.1117/1.NPh.6.1.015001. 

Tong Y, Frederick BD. Time lag dependent multimodal processing of concurrent fMRI and near-infrared spectroscopy (NIRS) data suggests a global circulatory origin for low-frequency oscillation signals in human brain. Neuroimage. 2010;53(2):553-64. 

Tong Y, Bergethon PR, Frederick BD. An improved method for mapping cerebrovascular reserve using concurrent fMRI and near-infrared spectroscopy with Regressor Interpolation at Progressive Time Delays (RIPTiDe). Neuroimage. 2011;56(4):2047-57. 

Tong Y, Lindsey KP, Frederick B. Partitioning of physiological noise signals in the brain with concurrent near-infrared spectroscopy and fMRI. J Cereb Blood Flow Metab. 2011;31(12):2352-62. 

Tong Y, Frederick Bd. Concurrent fNIRS and fMRI processing allows independent visualization of the propagation of pressure waves and bulk blood flow in the cerebral vasculature. Neuroimage. 2012;61(4):1419-27.

Tong Y, Hocke LM, Nickerson LD, Licata SC, Lindsey KP, Frederick BD. Evaluating the effects of systemic low frequency oscillations measured in the periphery on the independent component analysis results of resting state networks. Neuroimage. 2013;76:202-15. 

Tong Y, Frederick BD. Tracking cerebral blood flow in BOLD fMRI using recursively generated regressors. Hum Brain Mapp. 2014;35(11):5471-85. 

Tong Y, Hocke LM, Frederick BD. Short repetition time multiband echo-planar imaging with simultaneous pulse recording allows dynamic imaging of the cardiac pulsation signal. Magn Reson Med. 2014;72(5):1268-76. 

Tong Y, Yao JF, Chen JJ, Frederick BD. The resting-state fMRI arterial signal predicts differential blood transit time through the brain. J Cereb Blood Flow Metab. 2019;39(6):1148-1160. 

Tong Y, Hocke LM, Frederick BB. Low frequency systemic hemodynamic "noise" in resting state BOLD fMRI: Characteristics, causes, implications, mitigation strategies, and applications. Front Neurosci. 2019;13:787. doi: 10.3389/fnins.2019.00787. eCollection 2019.

Yang HS, Liang Z, Yao JF, Shen X, Frederick BD, Tong Y. Vascular effects of caffeine found in BOLD fMRI. J Neurosci Res. 2019;97(4):456-466.